Zebrafish Research

Fish and mice share considerable genetic similarities and basic biological characteristics with humans, making them suitable model organisms for the development of any kind of medical technologies and therapeutic drugs or even for the investigation of the foundations of disease. Legislation recognizes that mammals like mice experience more conscious suffering compared to "lower" organisms such as fish. Consequently, zebrafish have become the second most utilized animal in biomedical research after mice, primarily used in the early phases of experimental processes to limit the use of mice to only the final validation stages. At KIT we have a long standing experience in zebrafish research also for biomedical investigations



Blood vesselsF. LeNoble@KIT
KIT Researchers Discover Novel Cell Type that Controls the Formation and Growth of New Blood Vessels

Molecular Code Stimulates Pioneer Cells to Build Blood Vessels in the Body. Cardiovascular diseases, including stroke and myocardial infarction, are the world's leading causes of mortality, accounting for over 18 million deaths a year. Ferdinand le Noble and his team has now identified a new cell type in blood vessels responsible for vascular growth. This discovery may allow for novel therapeutic strategies to treat ischemic cardiovascular diseases, i.e. diseases that are caused by reduced or absent blood flow. Nature Communications (DOI: 10.1038/s41467-024-47434-x ). Professor Ferdinand le Noble says: “To explore the therapeutic avenues, we are collaborating with chemists, tissue engineers, and artificial intelligence (AI) specialists at the 3ROCKIT platform of the Health Technologies Center established recently at Karlsruhe Institute of Technology (KITHealthTech).  We congratulate the team for this highly interesting scientific publication in Nature Communications.